Duke Criteria For Infective Endocarditis

Major Criteria:
1. Positive blood culture

• typical organism in 2 separate cultures or
• persistently +ve blood culture 

2. Endocardium involved

• positive echocardiogram  showing vegetations, abscess or dehiscence of prosthetic valves or
• new valvular regurgitation (change in murmur is not sufficient)

Minor Criteria:

1. Predisposition like cardiac lesion, Iv drug abuse

2. Fever >38C

3. Vascular /Immunological signs

4. Positive blood culture that does not meet major criteria

5. Positive echocardiogram that does not meet major criteria.

Definite infective endocarditis is diagnosed if 2 major OR 1 major and 3 minor OR all 5 minor criteria are met.